Immunocompromised patients lack critical components of the adaptive and/or innate immune system required to counteract infection. These deficits can also reduce the effectiveness of vaccinations to less than 50%.6
Patients with bacterial or viral co-infections are more likely to progress to lower respiratory illness, suffer life-threatening disease, and experience prolonged hospitalizations.8,12
HSCT recipients13:
Up to 80%
Solid organ transplant recipients14:
Up to 43%
Patients receiving myelosuppressive chemotherapy15:
Up to 83%Learn about the advantages and limitations of management strategies for RVI in immunocompromised patients.
Images and descriptions are for illustrative purposes only
HSCT, hematopoietic stem cell transplant; RSV, respiratory syncytial virus; RVI, respiratory viral infection.
1. Centers for Disease Control and Prevention. Disease burden of influenza. Accessed February 2, 2021. https://www.cdc.gov/flu/about/burden/index.html. 2. Henrickson KJ. Clin Microbiol Rev. 2003;16(2):242-264. 3. Edwards KM, et al. N Engl J Med. 2013;368(7):633‐643. 4. Centers for Disease Control and Prevention. Respiratory syncytial virus infection: trends and surveillance. Accessed February 2, 2021. https://www.cdc.gov/rsv/research/us-surveillance.html. 5. Killerby ME, et al. J Clin Virol. 2018;101:52-56. 6. Centers for Disease Control and Prevention. Immunogenicity, Efficacy, and Effectiveness of Influenza Vaccines. Accessed February 2, 2021. https://www.cdc.gov/flu/professionals/acip/immunogenicity.htm. 7. Martínez-Roig A, et al. Arch Bronconeumol. 2015;51(1):5-9. 8. Wiegers HMG, et al. BMC Infect Dis. 2019;19(1):938. 9. Choi SH, et al. Am J Respir Crit Care Med. 2012;186(4):325‐332. 10. Walker E, et al. Influenza Other Respir Viruses. 2014;8(3):282‐292. 11. Griffiths C, et al. Clin Microbiol Rev. 2017;30(1):277-319. 12. Mazur NI et al. Clin Infect Dis. 2017;64(4):443-450 13. Lewinsohn DM, et al. Antimicrob Agents Chemother. 1996;40(11):2555-2557. 14. Khalifah AP, et al. Am J Respir Crit Care Med. 2004;170(2):181‐187. 15. Whimbey E, et al. Clin Infect Dis. 1995;21(2):376-379.
